valeriana officinalis mechanism of action

However, they say that the findings of other studies go against these results, showing that valerian caused little or no difference in these symptoms. The authors noted that some research showed that valerian improved markers of sleep, such as overall sleep time, and reduced the severity of insomnia. However, the research on these effects is conflicting.Ī review in Evidence-Based Complementary and Alternative Medicine looked at 17 different articles on the effects of valerian on sleep. Valerian root is a known sedative and may help many people reduce symptoms of anxiety and insomnia. Other experts believe that valerian exerts its sedative and antianxiety effects through the action of its potent antioxidants in areas of the brain involved with stress and emotion, such as the amygdala and hippocampus. How valerian interacts with GABA, however, remains a theory. This is similar to how prescription antianxiety drugs, such as diazepam (Valium), work. However, researchers still do not completely understand the herb’s effects.Ĭompounds in the root appear to interact with important components of the nervous system, such as gamma-aminobutyric acid (GABA), a chemical messenger in the brain.Ī study published in BMC Complementary Medicine and Therapies noted that compounds in valerian root, such as valerenic acid, may interact with GABA and its receptors to create the noted antianxiety effect. Proponents say the herb has a relaxing effect that calms anxiety, allowing a person to rest.Ī study in Frontiers in Neuroscience noted that people around the world recognize valerian as an effective herbal sedative. Valerian root is a common herb in traditional and folk medicine. Share on Pinterest Image credit: Gregory_DUBUS/Getty Images

Valeriana officinalis mechanism of action